The Third International Consensus Definitions for Sepsis and Septic Shock by JAMA

Extracted Video Presentation:

Time: 0:00 – 0:14

Sepsis is a life-threatening clinical syndrome that develops when the body responds to infection injures its own tissues and organs.

Time:  0:15 – 0:55

Clinical criteria for diagnosing sepsis were first proposed in 1991 and last updated in 2001. But a lot has happened since. So now a task force of critical care, infectious disease and surgical pulmonary specialist has published the third international consensus definitions for Sepsis and Septic Shock that take the advantage of advances in the science of Sepsis and ability to test and propose Sepsis criteria, against patient outcomes using electronic health records data.

Time: 0:58 – 1:27

The G defines Sepsis as life-threatening organ dysfunction caused by dysregulated host response to infection. In clinical terms, patients with Sepsis has suspected or documented infection and an acute change in the Sepsis-related organ failure assessment or sofa score of greater than or equal to 2.

Time:  1:31 – 1:53

The G recommends the use of the bedside score; the Quick SOFA or QSOFA Score comprising an increased respiratory rate, alterations in cognition and low blood pressure to identify patients outside critical care settings with suspected infections likely to have poor outcomes typical of Sepsis.

Time: 1:55 – 2:43

Finally, they define septic shock as Sepsis with abnormalities and circulatory physiology and cellular metabolism in the absence of hypovolemia profound enough to increase mortality. The authors acknowledge that there are no reference standards that diagnosing Sepsis. And the definition of Sepsis is and should remain a working progress.

For full article view JAMA Sepsis.

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